From Wikipedia,
the free encyclopedia
Caco-2 refers to a cell
monolayer absorption model.
Cell-based functional
assays, such as the Caco-2
drug transport model for assessing
intestinal transport, are
extremely valuable for screening
lead compounds in
drug discovery. The Caco-2
cell line is widely used in in
vitro assays to predict the
absorption rate of candidate drug
compounds across the intestinal
epithelial cell barrier. The assay
requires that drug absorption
rates be determined 21 days after
Caco-2 cell seeding to allow for
monolayer formation and cell
differentiation.
